Autoimmune disease is exploding in America.  At this point, these disorders are the third leading cause of morbidity and mortality in the industrialized world, surpassed only by cancer and heart disease.1   Approximately 8 percent of the United States population is affected which means about 24 million people.  To provide a context to evaluate the impact of autoimmune diseases, cancer affectes approximately 9 million people and heart disease affected approximately 22 million people in the United States. 2

What is Autoimmune Disease?

Your immune system is a series of cells and chemical messengers that keep us safe from infection and help us with the healing process.  It is highly sophisticated and was carefully designed to be able to recognize YOU from anything that is not you.  We call it Self vs. Non-Self.  These cells are like the Special Forces of your body, very deadly and highly trained.  Bacteria, parasites, viruses and cancer cells are being destroyed constantly in your body by this silent assassin to keep you safe.

Unfortunately and for many different reasons, your immune system can be thrown out of balance and become dysregulated.  No longer can it distinguish between Self and Non-Self and it starts to attack your body!  Remember, this system was trained to fight relentlessly until its foe is completely gone.  It can use special messengers to recruit more attackers all the time and your body is happy to supply them, thinking it is under attack.  The problem is that you may have developed antibodies against your own thyroid, gastrointestinal tract or even brain!   The type of tissue that is destroyed in this process determines the type of autoimmune disease.  There are many different AI diseases that have been identified, such as rheumatoid arthritis (RA), multiple sclerosis (MS), lupus (SLE), Hashimoto’s Thyroiditis, Crohn’s disease, ulcerative colitis (UC), Type I Diabetes, Sjogren’s syndrome, scleroderma and celiac disease (CD).  ‘Autoimmune diseases can affect virtually every site in the body.  At least 15 diseases are known to be the direct result of an autoimmune response, and circumstantial evidence links more than 80 conditions to autoimmunity.’3

AI disease is usually progressive over time

There is no cure for most AI diseases. AI patients generally suffer more and more symptoms of tissue destruction over time. Conventional treatment is focused on suppressing the immune response and controlling symptoms but little is offered to the patient in regards to modulating the autoimmunity and avoiding triggers that cause flare-ups of the autoimmune response. As a result, AI conditions tend to cause more and more tissue destruction over time, eventually leading to severe tissue destruction and organ failure in many cases.

Most AI disease remains undiagnosed

“Collectively autoimmune diseases have been identified in about 24 million people in the U.S., and only 1/3 are diagnosed. That means about 72 million people have an AI disease. It’s not looked for. Our system waits until the signs and symptoms are severe enough with organ failure and irreversible damage before we identify it.”4

Progression of Autoimmune Disease

Another thing we know about AI disease is that when people have antibodies against one known tissue type, there is likely other antibodies against other tissue as well. In other words, when a person is diagnosed with AI disease, they are at high risk of developing other autoimmune diseases during their lifetime. It is very rare that only one tissue type is targeted by the immune system. When we look at people with AI disease, they may have multiple types of tissue being targeted that have not yet been identified. For example, the literature shows people with thyroid autoimmune disease have over a 50% chance of being affected by another autoimmune disease.5

There really is little hope in the conventional model of healthcare for patients with autoimmunity since the focus of treatment is suppression of the immune system. These immuno-suppressive agents come with significant adverse effects, including risk of various infections and inability to fight infection when needed.

As part of our multifaceted approach to treating the underlying issues, we use specific gut treatment, and immune modulating therapies.  New research (5) has also shown the powerful impact that fasting can have on immune system modulation, so that is a part of TheOptimumU protocols as well.


  1. The Journal of Immunology, 2005, 175: 4119–4126.

  2. NIH. Autoimmune Diseases Coordinating Comm. Autoimmune Diseases Research Plan. 2006


  4. Jeffrey S. Bland, Ph.D.; Metagenics Educational Programs. 2006

  5. Nature Medicine 2015